A new article is now available on Nat Commun.

We are proud to announce that our team’s research on 𝐮𝐥𝐭𝐫𝐚𝐬𝐞𝐧𝐬𝐢𝐭𝐢𝐯𝐞 𝐦𝐚𝐠𝐧𝐞𝐭𝐢𝐜 𝐩𝐚𝐫𝐭𝐢𝐜𝐥𝐞 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 𝐨𝐟 𝐥𝐮𝐧𝐠 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐢𝐨𝐧 is officially published in Nature Communications!💥

We leveraged France’s very first Magnetic Particle Imaging (MPI) system installed at the CYCERON biomedical imaging platform, to demonstrate the efficacy of immuno-MPI for the diagnosis of pulmonary inflammation: a radiation-free diagnostic approach designed to detect inflammation at its earliest stages.

By targeting endothelial VCAM-1 expression, 𝐰𝐞 𝐜𝐚𝐧 𝐧𝐨𝐰 𝐦𝐚𝐩 𝐥𝐮𝐧𝐠 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐢𝐨𝐧 and 𝘮𝘰𝘯𝘪𝘵𝘰𝘳 𝘸𝘩𝘰𝘭𝘦-𝘣𝘰𝘥𝘺 𝘳𝘦𝘴𝘱𝘰𝘯𝘴𝘦𝘴 in several kinds of pulmonary inflammation-related disease models, including sepsis and bleomycin-induced pulmonary fibrosis model. This proof of concept paves the way for earlier diagnoses, personalized therapeutic decisions, and real-time monitoring of anti-inflammatory treatments.

–> 𝘞𝘩𝘺 𝘵𝘩𝘪𝘴 𝘮𝘢𝘵𝘵𝘦𝘳𝘴 ? Standard imaging only shows anatomical damage once a disease is already advanced. However, in severe respiratory conditions, such as pneumonia, acute COVID-19, pulmonary fibrosis, or lung transplant rejection, detecting early inflammation is critical to determining prognosis and guiding treatment.

🔗Link to the article : https://www.nature.com/articles/s41467-026-75724-z

3D immuno-MPI enables sensitive and specific detection of pulmonary VCAM-1 expression using targeted micron-sized particles

Congratulations to all the co-authors on this great achievement !! 👏

𝐋𝐨𝐨𝐤𝐢𝐧𝐠 𝐚𝐡𝐞𝐚𝐝, we acknowledge the Fondation Bettencourt Schueller for supporting our next milestone : 𝐰𝐞 𝐚𝐫𝐞 𝐧𝐨𝐰 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐢𝐧𝐠 𝐛𝐢𝐨𝐜𝐨𝐦𝐩𝐚𝐭𝐢𝐛𝐥𝐞 𝐚𝐧𝐝 𝐛𝐢𝐨𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐛𝐥𝐞 𝐩𝐫𝐨𝐛𝐞𝐬 to target distinct inflammatory markers across various disease contexts, taking our immuno-imaging approach one step closer to clinical translation 🎯

𝐁𝐫𝐚𝐢𝐧 𝐁𝐥𝐨𝐨𝐝 & 𝐌𝐞𝐦𝐨𝐫𝐲 𝐚𝐭 𝐂𝐚𝐞𝐧 𝐍𝐨𝐫𝐦𝐚𝐧𝐝𝐢𝐞 𝐈𝐧𝐬𝐭𝐢𝐭𝐮𝐭𝐞 (𝐁𝐁𝐌@𝐂)
UMR-S 1237 Physiopathology and Imaging of Neurological Disorders “PhIND”