{"id":629,"date":"2026-05-18T16:46:55","date_gmt":"2026-05-18T16:46:55","guid":{"rendered":"https:\/\/bindlab.cyceron.fr\/bindlab\/?page_id=629"},"modified":"2026-07-01T15:42:03","modified_gmt":"2026-07-01T15:42:03","slug":"projet-groupama-susac","status":"publish","type":"page","link":"https:\/\/bind-lab.fr\/?page_id=629","title":{"rendered":"Groupama Project – Susac"},"content":{"rendered":"\n
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Immuno-MRI and immuno-MPI for the diagnosis of Susac syndrome<\/em><\/h4>\n\n\n\n
Funded by Fondation Groupama pour la sant\u00e9<\/em> and Groupama Centre Manche<\/em><\/strong><\/h5>\n<\/div>\n\n\n\n
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Context and challenges<\/h4>\n\n\n\n

Susac syndrome is a rare disorder characterized by microvascular occlusions affecting the brain, retina, and inner ear, leading to multiple micro-infarctions. Its cause remains unknown, although a primary immune-mediated microangiopathy targeting these three organs is suspected. There is currently no disease-specific diagnostic test, delaying the initiation of appropriate treatment, despite the importance of early intervention to prevent irreversible neurological, visual, and auditory damage.<\/p>\n\n\n\n

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Objective<\/h4>\n\n\n\n

Our aim is to evaluate a novel contrast agent technology (submicrometric, biodegradable, and biocompatible particles developed in our laboratory), in an experimental model of Susac syndrome. This approach seeks to enable non-invasive diagnosis through immuno-MRI and\/or immuno-MPI, improving early and specific disease detection.<\/p>\n<\/div>\n\n\n\n

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Project coordinators<\/strong><\/h6>\n\n\n\n

Sara Martinez de Lizarrondo, PhD (U1237)
Maxime Gauberti, PhD (U1237)
Pr Denis Vivien, PhD (U1237)<\/p>\n\n\n\n

Related links<\/strong><\/h6>\n\n\n\n

Fondation Groupama “Vaincre les Maladies Rares”<\/a><\/p>\n\n\n\n

Groupama Centre Manche<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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Neuroinflammation imaging using immuno-MRI. The yellow circle indicates the LPS injection site in a mouse brain (left); intravenous injection of control particles with a non-specific IgG antibody shows no signal (middle), whereas particles functionalized to an anti-VCAM-1 antibody targeting activated endothelial cells, accumulate in the right hemisphere (right) (<\/em>Lizarrondo et al., 2022, Science Advances<\/em><\/a>).<\/em><\/p>\n<\/div>\n\n\n\n

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Neuroinflammation imaging using immuno-MRI. The yellow circle indicates the LPS injection site in a mouse brain (left); intravenous injection of control particles with a non-specific IgG antibody shows no signal (middle), whereas particles functionalized to an anti-VCAM-1 antibody targeting activated endothelial cells, accumulate in the right hemisphere (right) (<\/em>Lizarrondo et al., 2022, Science Advances<\/em><\/a>).<\/em><\/p>\n<\/div>\n\n\n\n

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Acknowledgment to Fondation Groupama<\/em><\/h3>\n\n\n\n

We are honored to acknowledge the financial support of the Fondation Groupama pour la sant\u00e9<\/a> and Caisse r\u00e9gionale Groupama Centre Manche<\/a>, which is enabling us to advance this research on Susac syndrome.<\/p>\n<\/div>\n\n\n\n

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Sharing our work – Soir\u00e9e de la Fondation Groupama (2026)<\/em><\/h4>\n\n\n\n

This support follows the successful completion of our previous project \u2018Molecular MRI for the Diagnosis of Primary Cerebral Vasculitis<\/strong>\u2019, also funded by the Fondation Groupama pour la sant\u00e9 and Caisse r\u00e9gionale Groupama Centre Manche<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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Immuno-MRI and immuno-MPI for the diagnosis of Susac syndrome Funded by Fondation Groupama pour la sant\u00e9 and Groupama Centre Manche Context and challenges Susac syndrome is a rare disorder characterized by microvascular occlusions affecting the brain, retina, and inner ear, leading to multiple micro-infarctions. Its cause remains unknown, although a primary immune-mediated microangiopathy targeting these […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":57,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-629","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"Juliette LOPEZ","author_link":"https:\/\/bind-lab.fr\/?author=2"},"uagb_comment_info":0,"uagb_excerpt":"Immuno-MRI and immuno-MPI for the diagnosis of Susac syndrome Funded by Fondation Groupama pour la sant\u00e9 and Groupama Centre Manche Context and challenges Susac syndrome is a rare disorder characterized by microvascular occlusions affecting the brain, retina, and inner ear, leading to multiple micro-infarctions. Its cause remains unknown, although a primary immune-mediated microangiopathy targeting these…","_links":{"self":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=629"}],"version-history":[{"count":79,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/629\/revisions"}],"predecessor-version":[{"id":2140,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/629\/revisions\/2140"}],"up":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/57"}],"wp:attachment":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}