{"id":625,"date":"2026-05-18T16:35:58","date_gmt":"2026-05-18T16:35:58","guid":{"rendered":"https:\/\/bindlab.cyceron.fr\/bindlab\/?page_id=625"},"modified":"2026-07-01T15:45:13","modified_gmt":"2026-07-01T15:45:13","slug":"atila","status":"publish","type":"page","link":"https:\/\/bind-lab.fr\/?page_id=625","title":{"rendered":"ATILA"},"content":{"rendered":"\n
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Targeting Tertiary Lymphoid Structures in Chronic Inflammatory Disorders patients<\/em><\/h4>\n\n\n\n
Funded by Agence Nationale de la Recherche<\/strong><\/h5>\n<\/div>\n\n\n\n
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Context and challenges<\/h4>\n\n\n\n

Tertiary lymphoid structures (TLS) are organized lymphoid aggregates that share characteristics with lymph nodes but arise in perivascular areas in response to chronic inflammation. TLS generate an in situ immune response in chronically inflamed tissues, and depending on the context, they are associated with a poor prognosis (e. g. autoimmune diseases) or with a positive impact during treatment (e. g. in many cancer types). Key players in local immunity in numerous human diseases, there is still no available tool to detect TLS in a non-invasive manner.<\/p>\n\n\n\n

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Objective<\/h4>\n\n\n\n

In the framework of this project, we are developing innovative targeting methods to achieve ultra-sensitive imaging of TLS. The envisioned applications in human medicine are broad, including the diagnosis of chronic inflammatory disorders and patient selection for immune checkpoint inhibitors in cancer. With the right contrast agent, we are working to obtain background-free \u201chotspot maps\u201d of TLS at submillimeter resolution.<\/p>\n<\/div>\n\n\n\n

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Project coordinator<\/strong><\/h6>\n\n\n\n

Sara Martinez de Lizarrondo, PhD (U1237)<\/p>\n\n\n\n

Related links<\/strong><\/h6>\n\n\n\n

ATILA – ANR<\/a><\/p>\n\n\n\n

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Left:<\/strong> Immunofluorescence of a colon section revealing a T-cell zone (red) adjacent to a B-cell zone (green), corresponding to TLS. Middle:<\/strong> Sagittal view of a T2*-weighted MRI sequence in a colitis mouse model before contrast agent injection. Right:<\/strong> Same sequence after injection of TLS-targeted MPIO, revealing black rounded structures corresponding to TLS.<\/p>\n\n\n\n

Up:<\/strong> Immunofluorescence of a colon section revealing a T-cell zone (red) adjacent to a B-cell zone (green), corresponding to TLS. Bottom left:<\/strong> Sagittal view of a T2*-weighted MRI sequence in a colitis mouse model before contrast agent injection. Bottom right:<\/strong> Same sequence after injection of TLS-targeted MPIO, revealing black rounded structures corresponding to TLS.<\/p>\n\n\n\n

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Acknowledgment to ANR<\/em><\/h3>\n\n\n\n

This project was funded by the French National Research Agency<\/a> (ANR).<\/p>\n<\/div>\n\n\n\n

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Targeting Tertiary Lymphoid Structures in Chronic Inflammatory Disorders patients Funded by Agence Nationale de la Recherche Context and challenges Tertiary lymphoid structures (TLS) are organized lymphoid aggregates that share characteristics with lymph nodes but arise in perivascular areas in response to chronic inflammation. TLS generate an in situ immune response in chronically inflamed tissues, and […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":57,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-625","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"Juliette LOPEZ","author_link":"https:\/\/bind-lab.fr\/?author=2"},"uagb_comment_info":0,"uagb_excerpt":"Targeting Tertiary Lymphoid Structures in Chronic Inflammatory Disorders patients Funded by Agence Nationale de la Recherche Context and challenges Tertiary lymphoid structures (TLS) are organized lymphoid aggregates that share characteristics with lymph nodes but arise in perivascular areas in response to chronic inflammation. TLS generate an in situ immune response in chronically inflamed tissues, and…","_links":{"self":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=625"}],"version-history":[{"count":28,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/625\/revisions"}],"predecessor-version":[{"id":2146,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/625\/revisions\/2146"}],"up":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/57"}],"wp:attachment":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}