{"id":570,"date":"2026-05-18T15:06:47","date_gmt":"2026-05-18T15:06:47","guid":{"rendered":"https:\/\/bindlab.cyceron.fr\/bindlab\/?page_id=570"},"modified":"2026-07-01T15:43:25","modified_gmt":"2026-07-01T15:43:25","slug":"ischemag","status":"publish","type":"page","link":"https:\/\/bind-lab.fr\/?page_id=570","title":{"rendered":"ISCHEMAG"},"content":{"rendered":"\n
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Theranostic treatment of ischemic stroke using magnetic hyperthermia<\/em><\/h4>\n\n\n\n
Funded by Agence Nationale de la Recherche<\/strong><\/h5>\n<\/div>\n\n\n\n
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Context and challenges<\/h4>\n\n\n\n

Around 80% of strokes occur when a blood clot (thrombus) obstructs the brain\u2019s blood flow, leading to what is known as an ischemic stroke. Current therapeutic options rely on administering clot-dissolving agents (thrombolysis) or physically removing the clot using a catheter (thrombectomy), yet their overall effectiveness remains limited. The treatment of thrombosis via thrombolysis is currently limited by the inherent proteolytic effect of the tissue-plasminogen activator (tPA), which is currently the only pharmacological treatment available for ischemic stroke. In this context, inorganic nanomaterials with their potential for multifunctionality, represent a promising and innovative avenue for developing combined diagnostic and therapeutic approaches against blood clots.<\/p>\n\n\n\n

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Objective<\/h4>\n\n\n\n

The elaboration of a new treatment strategy against stroke based on nano-engineered magnetic porous silica: biocompatible and biodegradable injectable particles that will allow a treatment combining the effects of magnetic hyperthermia with the delivery of tPA antithrombotic enzymes or antioxidants agents prealably loaded in the silica pores.<\/p>\n\n\n\n

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Coordination<\/strong><\/h6>\n\n\n\n

Damien MERTZ, PhD (IPCMS, Strasbourg)<\/p>\n\n\n\n

Local project partner<\/strong><\/h6>\n\n\n\n

Thomas Bonnard, PhD (INSERM U1237 PhIND)<\/p>\n\n\n\n

Related links<\/strong><\/h6>\n\n\n\n

ISCHeMAG – ANR<\/a><\/p>\n\n\n\n

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Illustration of the principle of the theranostic core@shell for anti-thrombosis applications.<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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TEM images showing controlled core@shell particle formation with increased shell size.<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n
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Acknowledgment to ANR<\/em><\/h3>\n\n\n\n

This project was funded by the French National Research Agency<\/a> (ANR).<\/p>\n<\/div>\n\n\n\n

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\"\"<\/a><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
<\/div>\n","protected":false},"excerpt":{"rendered":"

Theranostic treatment of ischemic stroke using magnetic hyperthermia Funded by Agence Nationale de la Recherche Context and challenges Around 80% of strokes occur when a blood clot (thrombus) obstructs the brain\u2019s blood flow, leading to what is known as an ischemic stroke. Current therapeutic options rely on administering clot-dissolving agents (thrombolysis) or physically removing the […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":57,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-570","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"Juliette LOPEZ","author_link":"https:\/\/bind-lab.fr\/?author=2"},"uagb_comment_info":0,"uagb_excerpt":"Theranostic treatment of ischemic stroke using magnetic hyperthermia Funded by Agence Nationale de la Recherche Context and challenges Around 80% of strokes occur when a blood clot (thrombus) obstructs the brain\u2019s blood flow, leading to what is known as an ischemic stroke. Current therapeutic options rely on administering clot-dissolving agents (thrombolysis) or physically removing the…","_links":{"self":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=570"}],"version-history":[{"count":24,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/570\/revisions"}],"predecessor-version":[{"id":2142,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/570\/revisions\/2142"}],"up":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/57"}],"wp:attachment":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}