{"id":542,"date":"2026-05-18T13:42:35","date_gmt":"2026-05-18T13:42:35","guid":{"rendered":"https:\/\/bindlab.cyceron.fr\/bindlab\/?page_id=542"},"modified":"2026-07-01T15:41:17","modified_gmt":"2026-07-01T15:41:17","slug":"magma-ok","status":"publish","type":"page","link":"https:\/\/bind-lab.fr\/?page_id=542","title":{"rendered":"MAGMA"},"content":{"rendered":"\n
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Targeting tertiary lymphoid structures using magneto-margination<\/em><\/h4>\n\n\n\n
Funded by the European Research Council Executive Agency<\/strong><\/h5>\n<\/div>\n\n\n\n
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Context and challenges<\/h4>\n\n\n\n

Tertiary lymphoid structures (TLS) are abnormal immune cell aggregates that form in non-lymphoid tissues during chronic inflammation, such as in cancer or autoimmune diseases, and their impact on disease is context-dependent. Due to their small size (a few hundred micrometers), TLS are not detectable with current imaging techniques and can only be identified through tissue biopsy, limiting their utility as biomarkers or therapeutic targets.<\/p>\n\n\n\n

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Objective<\/h4>\n\n\n\n

This project aims to develop new methods for non-invasive mapping of TLS using clinically available imaging modalities (MRI) and emerging technologies (MPI), and to target them therapeutically via magnetic hyperthermia in cases where their presence is linked to poor prognosis. 
We are developing particles in the submicrometric size range that are sensible to magnetic fields thanks to an ultra-high density packing of iron oxide and have a margination comparable to micro-sized particles.<\/p>\n\n\n\n

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Project coordinator<\/strong><\/h6>\n\n\n\n

Maxime Gauberti, MD, PhD<\/p>\n\n\n\n

Related links<\/strong><\/h6>\n\n\n\n

Horizon Europe research and innovation programme<\/a><\/p>\n<\/div>\n\n\n\n

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Schematic representation of TLS developing in chronically inflamed tissue, illustrating their progressive organization into a T-cell zone and a germinal center (Created with BioRender.com).<\/em><\/figcaption><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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Representative MRI images showing transverse sections of the colon in a DSS-induced colitis model. TLS detection after injection of TLS-targeting agents conjugated with monoclonal antibodies on their surface, with no TLS signal observed following injection of control particles functionalized with anti-IgG.<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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Magnetic hyperthermia targeting TLS in a colitis mouse model<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n
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An ERC Consolidator Grant<\/em><\/h3>\n\n\n\n

This project has received funding from the European Union’s <\/em>Horizon Europe research and innovation programme<\/em><\/strong><\/a> <\/em>under grant agreement N\u00b0 101170501<\/em><\/p>\n<\/div>\n\n\n\n

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Targeting tertiary lymphoid structures using magneto-margination Funded by the European Research Council Executive Agency Context and challenges Tertiary lymphoid structures (TLS) are abnormal immune cell aggregates that form in non-lymphoid tissues during chronic inflammation, such as in cancer or autoimmune diseases, and their impact on disease is context-dependent. Due to their small size (a few […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":57,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-542","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"Juliette LOPEZ","author_link":"https:\/\/bind-lab.fr\/?author=2"},"uagb_comment_info":0,"uagb_excerpt":"Targeting tertiary lymphoid structures using magneto-margination Funded by the European Research Council Executive Agency Context and challenges Tertiary lymphoid structures (TLS) are abnormal immune cell aggregates that form in non-lymphoid tissues during chronic inflammation, such as in cancer or autoimmune diseases, and their impact on disease is context-dependent. Due to their small size (a few…","_links":{"self":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=542"}],"version-history":[{"count":83,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/542\/revisions"}],"predecessor-version":[{"id":2139,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/542\/revisions\/2139"}],"up":[{"embeddable":true,"href":"https:\/\/bind-lab.fr\/index.php?rest_route=\/wp\/v2\/pages\/57"}],"wp:attachment":[{"href":"https:\/\/bind-lab.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}